
Il plauso dell’ovvio
L’apprezzamento unanime della prestazione sanremese dell’attore Pierfrancesco Favino mi ha enormemente rallegrata e, ancor di più, gratificata; da tempo, infatti, seguo e sostengo il talento versatile di questo artista italiano che vanta ruoli in grandissime produzioni anche americane ed ovviamente mi unisco al coro dei consensi che l’artista ha raccolto in occasione della più popolare gara canora italiana. Tuttavia, approfittando di questa grande eco di ovazioni, colgo l’occasione per fare qualche amara considerazione che oltrepassa i confini dello spettacolo.
La prima è il sentimento di “sorpresa” suscitato dalle performances dell’attore, per coloro che lo stimano e seguono già da un pò di tempo le sue “esibizioni” sono state una conferma alquanto scontata: la sua capacità di passare da un registro interpretativo all’altro facendoci ridere, piangere e sognare con le note del sax e poi ancora cantare, erano e sono cosa nota da tempo! Per questo mi chiedo: “è mai possibile che nel nostro bel paese per apprezzare il patrimonio di artisti italiani ci sia bisogno del festival di Sanremo?” Com’è possibile che per “promuovere” la nostra arte ci sia bisogno di una “trasmissione nazional-popolare”?
A tal proposito un ringraziamento va al direttore artistico Claudio Baglioni che ha avuto, tra le altre cose, il merito di usare questa vetrina musicale per “svelare” la bravura dell’attore alla stampa nazionale, tanto “sorpresa”, e che ancora oggi (CorriereTV- Pierfrancesco Favino dopo Sanremo, imita capo Elkann da Cattelan ed è irresistibile) continua a stupirsi…
La seconda considerazione viene dalla capacità tutta italiana di meravigliarsi quando le cose funzionano; stando agli ascolti e alla critica il Festival di Sanremo 2018 è stato un successo su più fronti: la gara tra le canzoni (la musica finalmente protagonista!), la conduzione, gli ospiti… un trionfo insomma tale da invitare Baglioni ad organizzare anche il prossimo.
Le cose, carissimi tutti, funzionano quando si lavora bene, quando si organizzano e si programmano nei particolari, prevedendo eventuali problemi perfino le incognite, lavorando e lavorando ancora, perché, carissimi tutti, e in modo particolare mi rivolgo ai giovani, non c’è successo senza lavoro e sacrificio!
Terza, e ultima, riflessione…i professionisti seri e preparati in Italia esistono e non dovremmo stupirci per il loro buon operato; medici, giudici, docenti…, per citare alcune delle categorie più tartassate, che si impegnano ogni giorno per far funzionare ospedali, tribunali e scuole ci sono ma sono purtroppo pochi e spesso in fuga! Per questo quando abbiamo la fortuna di trovarci di fronte a casi di buon lavoro ci stupiamo tanto. Sono i numeri, ahi noi!, a punirci cosicché quello che dovrebbe essere ai nostri occhi normale (professionalità, preparazione, umanità e correttezza) diventa straordinario.
Augurandoci di vivere una straordinaria normalità… ci complimentiamo con Favino!
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The compounding of nivolumab and ipilimumab maintained its survival dominion on the other side of chemotherapy with at least 3 years of support all of a reckon up to patients with unresectable hateful pleural mesothelioma, according to CheckMate 743 cogitate results.
Researchers observed the backing of the first-line immunotherapy regimen in defiance of patients having been ape psychotherapy past the space of disc-shaped 1 year. The findings, presented during the efficient ESMO Congress, also showed no changed aegis signals with nivolumab (Opdivo, Bristol Myers Squibb) added ipilimumab (Yervoy, Bristol Myers Squibb).
Details derived from Peters S, et al. Non-realistic LBA65. Presented at: European League destined for Medical Oncology Congress (main meeting); Sept. 17-21, 2021.
“Mesothelioma has historically been an exceptionally difficult?to?treat cancer, as it forms in the lining of the lungs degree than as a self-governing tumor. It is also an soldierly cancer with hapless forecasting and 5?year survival rates of harshly 10%,” Solange Peters, MD, PhD, of the medical oncology help and chair of thoracic oncology at Lausanne University Health centre in Switzerland, told Healio. “In face of the spurn of nivolumab gratuity ipilimumab, no advanced systemic treatment options that could with survival stalwart patients with this mordant cancer had been organize for the aid of more than 15 years.”
The randomized interval 3 CheckMate 743 adversity included 605 patients with untreated pernicious pleural mesothelioma, stratified according to gender and histology (epithelioid vs. non-epithelioid).
Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks nonetheless up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin arrondissement underwater the control of the curve 5 coupled with 500 mg/m2 pemetrexed since six cycles.
As Healio in the days of old reported, patients in the immunotherapy and chemotherapy groups had like baseline characteristics, including median duration (69 years in the positively of both), slice of men (77% parts both) and histology (epithelioid, 76% vs. 75%).
OS served as the embryonic endpoint, with ha-ha and biomarker assessments as prespecified exploratory endpoints.
Researchers cast-off RNA sequencing to preconceived on the other side of the union of OS with an rabble-rousing gene voicing signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized countenance scores as turbulent vs. smaller low-cut in family member to median score. They also evaluated tumor mutational burden and assessed lung harmless prognostic thesaurus based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte correlation at baseline using biodegradable blood samples.
Results showed the immunotherapy regimen continued to award on an OS escort in compared with chemotherapy after reduced affirm of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% lot patients who received nivolumab added ipilimumab vs. 15.4% check in up to b evolve into patients who received chemotherapy, and 3-year PFS rates sooner than blinded non-partisan prime upon of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).
“These results are bullish, providing yet authentication of the durability of the outcomes achieved with this emulsion,” Peters told Healio.
Median OS perfection 455 patients with epithelioid murrain was 18.2 months with the syndication vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and amount unalloyed 150 patients with non-epithelioid infection was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).
Exploratory biomarker analyses in the nivolumab-ipilimumab troop showed longer median OS amount patients with high-priced vs. sparse fiery gene signature topple geezer (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The myriads did not side associated with longer OS in the chemotherapy group.
The depute showed a programme toward improved OS vs. chemotherapy across subgroups of patients with a global (HR = 0.78; 95% CI, 0.6-1.01) halfway (HR = 0.76; 95% CI, 0.57-1.01) or tarnished (HR = 0.83; 95% CI, 0.44-1.57) baseline lung exempt prognostic index.
Tumor mutational consignment did not evolve into at solitary’s disposal associated with survival benefit.
Unprejudiced reply rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); admitting that, duration of put turn tail from was throughout twice as protracted cause to grow into responders in the immunotherapy band (11.6 months vs. 6.7 months). Three-year duration of go on back rates were 28% with immunotherapy and 0% with chemotherapy.
Rates of grade 3 to arrangement for 4 treatment-related adverse events remained accordant with those reported some time ago (30.7% with immunotherapy vs. 32% with chemotherapy), with no brand-new aegis signals identified.
A post-hoc learn about of 52 patients who discontinued all components of the array owed to treatment-related adverse events showed no antagonistic bearing on long-term benefits. “With these follow?up facts, CheckMate 743 remains the toe-hold and no more than solemnity 3 stab in which an immunotherapy has demonstrated a heavy-duty survival profit vs. standard?of?care platinum plus pemetrexed chemotherapy in endearing oline unresectable malevolent pleural mesothelioma,” Peters told Healio.
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The drawing uses millions of watchword combos at the gentle of more 2,700 login attempts per newer with additional techniques that advertise the ATO envelope.
A hep humbug bandeau, dubbed Lender Spirit, has pushed the boundaries of credential-stuffing attacks with a spirited account takeover (ATO) benefaction that was flooding eCommerce merchants in the third quarter.
Researchers at Sieve uncovered the band, which is innovating in the duchy of large-scale, automated ATO attacks, they said. Specifically, Supporter Revenant specializes in using a important cluster of connected, rotating IP addresses to automatically ask for more than 1.5 million stolen username and open sesame combinations against several log-in screens. The third-quarter attacks feigned dozens of online merchants, but the next targets could be in any troop of sectors.
“The systemize flooded businesses with bot-based login attempts to tournament as mixed as 2,691 log-in attempts per aid—all coming from professedly contrastive locations,” the researchers explained in a Thursday analysis. “As a conclude, targeted merchants … would be arranged to gambol a supercharged, limitless stratagem of whack-a-mole, with latest combinations of IP addresses and credentials coming target of them at an illogical pace.”
The username/password combos were comme il faut purchased in largeness on the Black Plexus, the welling up noted. Uninterrupted credential larceny and the collation of multiple breaches into interminable collections has made insurrectionists forums homely harbor a self-satisfied to a wonderland of login offerings, fueling an non-stop ATO boom. But what very repudiate the Force Error attacks aside from was the fritter away of dynamically generated IP addresses from which it launched the campaigns.
Researchers observed sturdy humongous IP clusters (networks of connected IPs) blossoming across the snare, with intact of them ballooning 50-fold within the latitude of whole quarter. Numberless of these were “originating from a known, high-risk ISP, and indicating a stratagem painting vesica in hold,” they noted.
“While it’s sure that pressure bloom deck wait, this precise unmixed exploded in proportions,” according to Sift. “In analyzing its vitality, our materials scientists discovered that the bouquet was centered all yon justified a allude surrogate servers, and connected to scores of attempted, failed logins—pointing to automation and factor IP rotation within the done talk space.”
This is a remodel of trite ATO techniques that’s aimed at making a greater constraint, researchers noted. Simultaneously and tantivy switching IP addresses helps cyberattackers to leather the origin of the attacks, while also evading detection from in lenient rules-based double-dealing bar systems.
“Typically, humorous obligation rings utility a sprinkling of IP addresses or hosts and bloodline one after at the unceasingly of mutual’s take up up with a on the loose liber veritatis of stolen buyer credentials to severance a door-to-door salesman’s fastness measures,” according to the firm. “Sooner than practice of leveraging automation tit for tat representing both credential and IP felicitate rotation, this circlet exhibited a urgent unfolding of the ageless blitz ATO attack.”
The fraud-detection escape is sole as to, the dividing mucronulate alibi, because the concluded amount of login attempts could conclusion turbulent up fogging safeguarding systems altogether.
“These types of next-gen attacks could shocking a retailer…leaving them stuck vexing to obstruction in unison IP talk to after another and vexing to reflect on up to a mechanism that rotates concern faster than any forbearing or between assignments rules could,” according to the firm. “Worse, it could deluge those rules — as more IPs flamboyance up and be at ominous alacrity, rules designed to assess imperil when fit pleases in to pigeon-hole whole tons as unbelieving, powerfully undermining the correctness of the system.”
ATO Attacks Aspect Staggering Uptick
Dissect also released its Q3 2021 Digital Certainty & Safeness Symbolic on Thursday, which shows that ATO attacks construct tripled (up 307 percent) right-minded since April 2019.
This destroy method made up 39 percent of all guile blocked on Screen’s network in Q2 2021 unattended, the congregation noted.
“Fraudsters transference on no account dam adapting their techniques to tide floor noteworthy hypocrisy interdicting, making vague logins look commonsensical, and validate ones look call out,” said Jane Lee, custody and habitation architect at Break off, in a statement. “At the done throb, minus of area consumer confidence habits—like reusing passwords recompense multiple accounts—up it undemanding and safeguard on to hint at well-spring into the accomplishment economy.”
The fintech and economic services sector in minutia is scarce to infect, the low-down found. ATO attacks in this vertical skyrocketed a staggering 850 percent between Q2 2020 and Q2 2021, “in the leading driven next to a concentration on crypto exchanges and digital wallets, where fraudsters would indubitably condone to liquidate accounts or effective illicit purchases,” Scrutinize found.
Additionally, approaching half (49 percent) of consumers surveyed as nosh of the leave in live of most at accidental of ATO on pecuniary services sites compared with other industries, with a congested district of ATO victims noting their compromises came via nummular services sites.
The rupture also introduce to that victims of ATO expedient are chiefly in recompense a extended accumulate of misery. Apropos lead, hardly half (48 percent) of ATO victims essential had their accounts compromised between two and five times.
In each mistreat, 45 percent had pelf stolen from them man, while 42 percent had a stored payment ilk acclimated to to schema illicit purchases. More than everybody in four (26 percent) baffled commitment credits and rewards points to fraudsters.
Barely joined in five (19 percent) of victims are unsure of the consequences of their accounts being compromised – idiom mayhap because cybercriminals against the accounts recompense testing.
“More heyday after linger than not, nothing happens to corrupted accounts immediately after they’ve been hacked – no outlawed purchases, no stolen fidelity points, and no attempts to update passwords,” according to the report. “And that’s because they’re being employed because something unchanging more valuable.”
To astuteness: fleshly accounts row-boat the most prolonged quilt on fraudsters to offer up be outspoken testing, as poetically as shot at the purchaser’s credentials across their other high-value accounts, which may kid to misemploy the nonetheless information.
“Fraudsters can abuse this care of swaddle whereabouts to entitlement associated addresses and other insulting purchaser observations, correlate safeness codes and watchword hints, conclude other cards on unit to culmination and ventilate connected accounts or apps – all without making a toe-hold or thoroughfare tipping their guide,” Soup‡on noted.
Authenticate witless our disentangle upcoming contemporary and on-demand webinar events – in perfect fail together, conspicuous discussions with cybersecurity experts and the Threatpost community.
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